Amyotrophic Lateral Sclerosis Essay -- ALS Medical Medicine Essays

Amyotrophic sidelong SclerosisABSTRACT At this time, Amyotrophic Lateral Sclerosis(ALS) is a very confusing and elusive disorder. While the clinical foundation and diagnosis of ALS dates back to the early 1900s, with Charcot being the first to scientifically report and document his findings, there simply has not been definitive order since that time for the etiology for ALS. This fundamental problem has befuddled the most hooked researchers and its ensuing resultant has eluded the most clever experiments for some 80 years. This melodic theme is being written to address some of the most plausible view causes which have come to the forefront of ALS research in the cash in ones chips few years. This paper ordain also try to tackle the dangerous task of possibly uniting some of the findings and results of experiments from all over the realness in the last 4 years. While an exact, definitive etiology, treatment, or answer is not possible at this time, there does seem to be a fe w underlying trends and findings that have reinforced their own importance. These are the findings that exit be evaluated and will hopefully act as a coevals for, perhaps a premature, minimally complete conclusion of the available puss of knowledge that has been amassed on ALS. In addition to this, possible treatment, including pharmacological intervention, will be reviewed. INTRODUCTION ALS is a affection of the skeletal potent beat back neurons throughout the nervous system that usually affects both upper berth and lower take neurons. The progressive wasting and weakness of muscles that have scattered their nerve supply is a characteristic sign of lower motor neuron damage signs of spasticity and exaggerated reflexes are indications of damage to the upper motor neur... ...0. Rowland. Babinski and the diagnosis of amyotrophic lateral sclerosis. Neurological Institute. 1993. Vol. 33, 1. 11. Hubert and Blanchard. Pertussis toxin Pretreatment abolishes the inhibitory effect of Riluzole and carbachol on D-(3H)aspartate release from cultured cerebellar Granule cells. Neuroscience Letters, 1992. Vol. 140, pp. 251--254. 12. Cheramy, Barbeito, Godeheu and Glowinski. Riluzole inhibits the release of Glutamate in the caudate nitty-gritty of the cat in vivo. Neuroscience Letters, 1992. Vol. 147, pp. 209--212. 13. Benoit and Escande. Riluzole specifically blocks in-activated Na channels in myelinated nerve fibre. European Journal of Physiology, 1991. Vol. 419, pp. 603-609. 14.Drachman and Kuncl. Amyotrophic lateral sclerosis An un-conventional autoimmune disease? Annals of Neurology, 1989. Vol. 26, pp. 269-274.(Outdated, but useful)